Glycobiological Insights in Characterization and Targeting of Umbilical Cord Blood Derived Stem Cells
نویسندگان
چکیده
............................................................................................................ 8 REVIEW OF THE LITERATURE .......................................................................... 9 1. UMBILICAL CORD BLOOD STEM CELLS .................................................. 9 1.1 Umbilical cord blood as a stem cell source .......................................... 9 1.2 Umbilical cord blood stem and progenitor cells ................................. 11 1.2.1 Hematopoietic stem cells .................................................................. 11 1.2.2 Multipotent mesenchymal stromal cells ......................................... 14 1.3 Umbilical cord blood banking and therapeutic use ........................... 18 1.4 Homing and engraftment of stem and progenitor cells ..................... 21 2. GLYCOBIOLOGY ......................................................................................... 23 2.1 Glycosyltransferases ........................................................................... 23 2.2 Glycan diversity .................................................................................. 24 2.2.1 Glycoproteins ................................................................................... 26 2.2.2 Glycosphingolipids ........................................................................... 26 2.3 Lectins ................................................................................................. 27 2.4 Glycobiology of therapeutic stem cells ............................................... 29 2.4.1 Stem cell glycome ............................................................................. 29 2.4.2 Glycan markers of stem cells ....................................................... 30 2.4.3 Selectins in stem cell homing .......................................................... 32 2.4.4 Stem cell glycoimmunology .......................................................... 33 2.4.5 Glycan engineering .......................................................................... 34
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